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Search Results for " rho-associated protein kinase "

20

Compounds

Cat No. Product Name Synonyms Targets
T2155 Thiazovivin ROCK
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T2633 GSK429286A RHO-15 ROCK
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T7885 Afuresertib hydrochloride ROCK , Akt , PKC
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
TQ0187 SR-3677 ROCK , Autophagy
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T12747 ROCK2-IN-2 ROCK
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T1870 Y-27632 ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T7391 SAR407899 ROCK , Rho
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T15798 LX7101 ROCK , LIM Kinase , PKA
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T14960 Chroman 1 ROCK
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T7648 HA-100 Myosin , PKA , PKC
HA-100 is an inhibitor of protein kinase
TQ0183 Narciclasine Lycoricidinol ROCK
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T12746 ROCK inhibitor-2 ROCK
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T7301 BDP5290 ROCK
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T14989 CMPD101 ROCK , GRK , PKC
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T1898 RKI-1447 RKI1447 ROCK
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T1911 Afuresertib GSK2110183C,GSK2110183 ROCK , Akt , PKC
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T4095 ZINC00881524 ROCK inhibitor ROCK
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
T7764 CCG-222740 ROCK , Rho , Ras
CCG-222740 is an inhibitor of Rho/MRTF pathway
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